Anaplastic lymphoma kinase positive large B-cell lymphoma mimicking as plasma cell neoplasm: A rare case report

• Published in: Journal of Applied Hematology Vol. 14; no. 3; pp. 252 - 254
• Main Authors: Ghosh, Kaustav, Sanyal, Chirasree, Mandal, Prakas
• Format: Journal Article
• Language: English
• Published: Wolters Kluwer India Pvt. Ltd 01.07.2023; Medknow Publications and Media Pvt. Ltd; Wolters Kluwer Medknow Publications
• Subjects: anaplastic lymphoma kinase positive; B cells; cervical lymph node biopsy; nasal mass; Non-Hodgkin's lymphomas; plasmacytoma; Vincristine; Anaplastic lymphoma kinase positive; nasal mass; cervical lymph node biopsy; plasmacytoma
• ISSN: 1658-5127; 2454-6976
• DOI: 10.4103/joah.joah_40_23

Anaplastic lymphoma kinase positive (ALK+ve) large B-cell lymphoma (LBCL) is a rare, aggressive subtype of diffuse LBCL with unique morphological characteristics and unusual immunophenotypic features that have substantial overlap with other hematologic and nonhematologic neoplasms. Here, we present a 48-year-old male who presented with progressive swelling on both sides of the neck and left eye followed by protruding mass in the left nose over a span of 6 months. Based on the biopsy findings of the left nasal mass, a plasma cell neoplasm was initially diagnosed; later on the diagnosis was modified as ALK + ve LBCL based on the aggressive clinical course and biopsy findings of cervical lymph node. The patient was started on chemotherapy and is tolerating well.