Synthesis, biological activities, and future perspectives of steroidal monocyclic pyridines
Steroidal pyridines are a class of compounds that have been the subject of extensive research in recent years due to their potential biological activities. The introduction of a pyridine ring into the steroid skeleton can significantly alter the chemical and biological properties of the compound, ma...
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| Published in | MedChemComm Vol. 14; no. 1; pp. 1934 - 1972 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Royal Society of Chemistry
18.10.2023
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Steroidal pyridines are a class of compounds that have been the subject of extensive research in recent years due to their potential biological activities. The introduction of a pyridine ring into the steroid skeleton can significantly alter the chemical and biological properties of the compound, making it more potent and/or selective for a particular target. Different synthetic methods have been developed for the preparation of steroidal pyridines. This review provides an overview of the synthesis, biological activities, and future perspectives of steroidal monocyclic dihydropyridines, tetrahydropyridines, and pyridines from 2005 to the present. The different synthetic methods that have been developed for the preparation of these steroids are discussed, as well as the proposed mechanisms and the biological activities that have been reported. Finally, the potential of steroidal monocyclic pyridines for the development of new drugs is discussed. This review is intended to provide a comprehensive overview of the field of steroidal monocyclic pyridines for researchers and scientists who are interested in this area of research. It is also hoped that this review will stimulate further research into the synthesis and biological activities of steroidal pyridines to develop new and improved drugs for the treatment of diseases.
The current review highlights the synthesis and biological activities of steroidal monocyclic pyridines. The synthetic approaches, proposed mechanisms, biological activities are described. |
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| Bibliography: | https://oa.enpress-publisher.com/index.php/Pha/about/editorialTeam Pharmaceutics (2018). Dr. Khaled M. Elattar was born in Menyet Sammanoud, Aga, El-dakahlia, Egypt (1979). He received his B.Sc. in 2002 from the Faculty of Science, Mansoura University, Egypt, and his M.Sc. in 2006 from the Faculty of Science, Benha University, Benha, Egypt. He obtained his Ph.D. in Organic Chemistry in 2011 from the Faculty of Science, Mansoura University, Egypt (Ph.D. supervisors: Prof. A. A. Fadda and Prof. A. S. Fouda). He was a Lecturer in Organic Chemistry at the Faculty of Education of the Sert University, Sert, Libya from 2012-2015. He is a member of the Egyptian Chemical Society. He is a reviewer for some international scientific journals. His main research interests are in the fields of organic synthesis, the synthesis of heterocyclic compounds of pharmaceutical interest and medicinal chemistry. He joined the editorial board of OA Journal - Dr. Mohamed M. Hammouda was born in Mansoura, Egypt, in 1983. He received his B.Sc. in 2004 from the Faculty of Science, Mansoura University, Egypt, and his M.Sc. in 2008 from the Faculty of Science, Mansoura University, Mansoura, Egypt. He obtained his Ph.D. in Organic Chemistry in 2013 from the Faculty of Science, Mansoura University, Egypt (Ph.D. thesis: Synthesis and Reactions of some New Isatin Mannich Bases and Related Compounds of Expected Biological Activity). In 2013 he joined the Erasmus Mundus postdoctoral fellowship, Laboratory of Organic and Bio-Organic Synthesis, Gent University, Belgium. His post-doctoral research was in the development of a new type of chiral catalyst for a wide variety of enantioselective reactions. In 2017 he joined the Chemistry Department, Faculty of Science, Mansoura University as a Lecturer of Organic Chemistry, "Synthesis of nitrogen-containing compounds for antioxidant activity". In 2021 he joined the Department of Chemistry, College of Science and Humanities in Al-Kharj, Prince Sattam Bin Abdulaziz University, Saudi Arabia as an Assistant Professor of Organic Chemistry. . ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 |
| ISSN: | 2632-8682 2040-2503 2632-8682 2040-2511 |
| DOI: | 10.1039/d3md00411b |