Serum concentrations of procollagen type III aminoterminal peptide in growing dogs with hip dysplasia

The aim of the present study was to investigate the use of procollagen type III aminoterminal peptide (PIIINP) measurements in serum as an indicator of progress of fibrosis of coxofemoral joint capsules in hip dysplasia in immature dogs. High serum concentrations of PIIINP may indicate ongoing fibro...

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Published inActa veterinaria scandinavica Vol. 36; no. 1; pp. 157 - 160
Main Authors Madsen, J S, Svalastoga, E
Format Journal Article
LanguageEnglish
Published England BioMed Central 01.01.1995
Subjects
Age Factors
Analysis of Variance
Animals
Biomarkers
Brief Communication
Dogs
Hip Dysplasia, Canine - blood
Peptide Fragments - blood
Procollagen - blood
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Summary:The aim of the present study was to investigate the use of procollagen type III aminoterminal peptide (PIIINP) measurements in serum as an indicator of progress of fibrosis of coxofemoral joint capsules in hip dysplasia in immature dogs. High serum concentrations of PIIINP may indicate ongoing fibrosis with enhanced synthesis and deposition of fibrillar type III collagen, or an alteration in degradation and elimination of circulating PIIINP ( Hørslev-Petersen et al. 1988a). Therefore, high concentrations of PIIINP in serum was expected in dogs with hip dysplasia, which is a developmental condition with capsular fibrosis and osteoarthritis ( Gay et al. 1986).
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ISSN:0044-605X
1751-0147
1751-0147
DOI:10.1186/BF03547714