Structures of Amamistatins A and B, Novel Growth Inhibitors of Human Tumor Cell Lines from Nocardia asteroides

Two new lipopeptides, amamistatins A and B, were isolated from Nocardia asteroides SCRC-A2359, and their absolute stereostructures were determined by spectroscopic and chemical analyses. Amamistatin A inhibited the growth of human tumor cell lines.

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Bibliographic Details
Published inTetrahedron Vol. 56; no. 35; pp. 6435 - 6440
Main Authors Kokubo, Susumu, Suenaga, Kiyotake, Shinohara, Chikara, Tsuji, Tomoko, Uemura, Daisuke
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 25.08.2000
Elsevier
Subjects
Chemistry
Chemistry, Organic
degradation
oxazoles
peptides
Physical Sciences
Science & Technology
stereochemistry
stereochemistry
peptides
oxazoles
degradation
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Summary:Two new lipopeptides, amamistatins A and B, were isolated from Nocardia asteroides SCRC-A2359, and their absolute stereostructures were determined by spectroscopic and chemical analyses. Amamistatin A inhibited the growth of human tumor cell lines.
ISSN:0040-4020
1464-5416
DOI:10.1016/S0040-4020(00)00591-3