Mode of delivery of women with Swyer syndrome in a German case series

• Published in: Journal of perinatal medicine Vol. 49; no. 6; pp. 725 - 732
• Main Authors: Weisshaupt, Karen, Henrich, Wolfgang, Neymeyer, Jörg, Weichert, Alexander
• Format: Journal Article
• Language: English
• Published: Germany De Gruyter 27.07.2021; Walter de Gruyter GmbH
• Subjects: Adult; Cesarean Section - methods; Childbirth & labor; Clinical outcomes; Delivery, Obstetric - methods; Differences of sex development; Elective Surgical Procedures - methods; Female; Germany - epidemiology; Gonadal Dysgenesis, 46,XY - diagnosis; Gonadal Dysgenesis, 46,XY - epidemiology; Gonadal Dysgenesis, 46,XY - physiopathology; Humans; Labor, Induced - methods; Live Birth; Obstetric Labor Complications - etiology; Obstetric Labor Complications - prevention & control; oocyte donation; Oocyte Donation - methods; Pregnancy; Pregnancy Complications - epidemiology; Pregnancy Complications - physiopathology; Pregnancy Complications - therapy; Pregnancy Outcome - epidemiology; Reproductive Techniques, Assisted; Reproductive technologies; Stillbirth; Swyer syndrome; Womens health; XY gonadal dysgenesis; Germany; XY gonadal dysgenesis; Swyer syndrome; oocyte donation
• ISSN: 0300-5577; 1619-3997
• DOI: 10.1515/jpm-2020-0562

For women with Swyer Syndrome, a 46,XY gonadal dysgenesis, full term pregnancies are possible after oocyte donation. According to literature, mode of delivery is almost always by Caesarean section for various reasons. Medical indications are multiple pregnancies and related complications, preeclampsia, an androgynous shaped pelvis and failed induction of labor. Elective Caesarean sections were performed based on maternal request and medical recommendation. Following careful examination and shared decision making, we planned a spontaneous delivery with a patient with Swyer syndrome and tested the different hypotheses regarding anatomical and functional features according to literature. In addition, deliveries of women with Swyer Syndrome were analyzed in a German multicenter case series. A total of seven women with Swyer syndrome with a total of 10 pregnancies were identified, who later gave birth to twelve live-born children. Seven out of 10 births were performed by elective and non-elective Caesarean section, three births took place vaginally. In summary, the risk of Caesarean section delivery has increased, but spontaneous delivery can be attempted in the event of inconspicuous findings.