Calcinosis Cutis in a Newborn with Transient Pseudohypoparathyroidism

Pseudohypoparathyroidism (PHP) is a heterogenous group of disorders characterized by hypocalcemia with hyperphosphatemia, increased serum concentration of parathyroid hormone (PTH), and insensitivity to the biological activity of PTH. Calcinosis cutis, the cutaneous deposition of calcium salts in th...

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Bibliographic Details
Published inIndian journal of pediatrics Vol. 78; no. 11; pp. 1424 - 1426
Main Authors Ergin, Hacer, Karaca, Abdullah, Ergin, Şeniz, Çördük, Nergül, Karabulut, Nevzat
Format Journal Article
LanguageEnglish
Published India Springer-Verlag 01.11.2011
Springer
Subjects
Adult
Biological and medical sciences
Calcinosis - chemically induced
Calcium Gluconate - adverse effects
Clinical Brief
Endocrinopathies
Female
General aspects
Gynecology
Humans
Infant, Newborn
Male
Medical sciences
Medicine
Medicine & Public Health
Metabolic diseases
Metals (hemochromatosis...)
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Other metabolic disorders
Parathyroids. Parafollicular cells. Cholecalciferol. Phosphocalcic homeostasis (diseases)
Pediatrics
Pseudohypoparathyroidism - drug therapy
Skin Diseases, Metabolic - chemically induced
Calcinosis cutis
Newborn
Pseudohypoparathyroidism
Endocrinopathy
Human
Pediatrics
Calcinosis
Tropical medicine
Skin
Transitory
Genetic disease
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Summary:Pseudohypoparathyroidism (PHP) is a heterogenous group of disorders characterized by hypocalcemia with hyperphosphatemia, increased serum concentration of parathyroid hormone (PTH), and insensitivity to the biological activity of PTH. Calcinosis cutis, the cutaneous deposition of calcium salts in the dermis, is a rare clinical symptom in infancy. The deposition of calcium in the skin may be classified as dystrophic, metastatic, idiopathic, and iatrogenic. Although a few infants with PHP and calcinosis cutis have been reported, to the authors’ knowledge, the combination of neonatal transient PHP and calcinosis cutis associated with calcium treatment has not been previously reported. The authors report a newborn boy with transient PHP presenting with early hypocalcemia, hyperphosphatemia, increased PTH levels, and calcinosis cutis after intravenous treatment of calcium gluconate.
ISSN:0019-5456
0973-7693
DOI:10.1007/s12098-011-0446-5