Parvovirus B19 Infection in a Fatal Case of Acute Liver Failure

B19V has been proposed as an etiologic agent for hepatitis, mainly in children, but this is a rare clinical occurrence. In this article, we report a case of non-A-E acute liver failure in an immunocompetent child with B19 infection. The clinical findings of severe anemia and pancytopenia combined wi...

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Bibliographic Details
Published inThe Pediatric infectious disease journal Vol. 36; no. 12; p. e355
Main Authors Leon, Luciane Almeida Amado, Alves, Arthur Daniel Rocha, Garcia, Rita de Cássia Nasser Cubel, Melgaço, Juliana Gil, de Paula, Vanessa Salete, Pinto, Marcelo Alves
Format Journal Article
LanguageEnglish
Published United States 01.12.2017
Subjects
Child
DNA, Viral - analysis
DNA, Viral - blood
Fatal Outcome
Female
Humans
Liver - virology
Liver Failure, Acute - virology
Parvoviridae Infections - diagnosis
Parvoviridae Infections - immunology
Parvoviridae Infections - virology
Parvovirus B19, Human - genetics
Parvovirus B19, Human - immunology
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Summary:B19V has been proposed as an etiologic agent for hepatitis, mainly in children, but this is a rare clinical occurrence. In this article, we report a case of non-A-E acute liver failure in an immunocompetent child with B19 infection. The clinical findings of severe anemia and pancytopenia combined with the detection of anti-B19 Immunoglobulin G (IgG), B19 DNA and B19 mRNA in liver indicate a persistent infection and suggest a diagnosis of parvovirus B19-associated acute liver failure.
ISSN:1532-0987
DOI:10.1097/inf.0000000000001731