Further Investigations on the Mode of Entry of Vaccinia Virus into Cells

National Institute for Medical Research, Mill Hill, London NW7 1AA, England Earlier results indicating that vaccinia virus entered L cells by a process of direct fusion between the virus envelope and the plasma membrane of the cell have been confirmed and extended using immuno-ferritin conjugates to...

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Bibliographic Details
Published inJournal of general virology Vol. 32; no. 2; pp. 275 - 282
Main Authors Chang, Annabella, Metz, D. H
Format Journal Article
LanguageEnglish
Published England Soc General Microbiol 01.08.1976
Subjects
Adsorption
Antigens, Viral - isolation & purification
Cell Membrane - immunology
Cell Membrane - microbiology
Ferritins
HeLa Cells
Immunologic Techniques
L Cells (Cell Line)
Vaccinia virus - growth & development
Vaccinia virus - immunology
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Summary:National Institute for Medical Research, Mill Hill, London NW7 1AA, England Earlier results indicating that vaccinia virus entered L cells by a process of direct fusion between the virus envelope and the plasma membrane of the cell have been confirmed and extended using immuno-ferritin conjugates to locate virus antigens on the host cell surface. After fusion, components of the virus envelope become rapidly dispersed in the plasma membrane. Fusion has also been observed as the predominant mode of entry of vaccinia virus into HeLa cells. Received 5 February 1976; accepted 31 March 1976.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0022-1317
1465-2099
DOI:10.1099/0022-1317-32-2-275