Synthetic studies on reveromycin A: Stereoselective synthesis of the spiroketal system

The 6,6-spiroketal system of reveromycin A ( 1), corresponding to the C 9-C 20 part, was stereoselectively synthesized and the absolute configuration at C 11, C 12, C 15, C 18 and C 19 of 1 was confirmed by the synthesis of the 5,6-spiroketal derivative degradated from 1. The 6,6-spiroketal system (...

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Published inTetrahedron letters Vol. 37; no. 37; pp. 6755 - 6758
Main Authors Shimizu, Takeshi, Kobayashi, Ryoichi, Osako, Katsuhisa, Osada, Hiroyuki, Nakata, Ta-i
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 09.09.1996
Elsevier
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
EUKARYOTIC CELL-GROWTH
INHIBITORS
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Summary:The 6,6-spiroketal system of reveromycin A ( 1), corresponding to the C 9-C 20 part, was stereoselectively synthesized and the absolute configuration at C 11, C 12, C 15, C 18 and C 19 of 1 was confirmed by the synthesis of the 5,6-spiroketal derivative degradated from 1. The 6,6-spiroketal system ( 2) of reveromycin A ( 1), an inhibitor of the mitogenic activity of epidermal growth factor (EGF), was stereoselectively synthesized.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(96)01460-8