Ca2+-dependent Transcriptional Control of Ca2+ Homeostasis

Intracellular free Ca2+ ions regulate many cellular functions, and in turn, the cell devotes many genes/proteins to keep tight control of the level of intracellular free Ca2+. Here, we review recent work on Ca2+-dependent mechanisms and effectors that regulate the transcription of genes encoding pro...

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Bibliographic Details
Published inThe Journal of biological chemistry Vol. 287; no. 38; pp. 31674 - 31680
Main Authors Naranjo, Jose R., Mellström, Britt
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 14.09.2012
American Society for Biochemistry and Molecular Biology
Subjects
Alternative Splicing
Animals
Calcineurin
Calcineurin - metabolism
Calcium
Calcium - metabolism
Calcium ATPase
Calcium Channels
Calcium Channels - metabolism
Cerebral Cortex - metabolism
Gene Expression Regulation
Homeostasis
Humans
Inositol 1,4,5-Trisphosphate Receptors - metabolism
Ions
Kv Channel-Interacting Proteins - metabolism
Mice
Minireviews
Models, Biological
Polymerase Chain Reaction - methods
Repressor Proteins - metabolism
Signal Transduction
Transcription Repressor DREAM
Transcription, Genetic
Transcriptional Regulation
Calcium ATPase
Calcium
Calcium Channels
Transcription Repressor DREAM
Calcineurin
Transcriptional Regulation
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Summary:Intracellular free Ca2+ ions regulate many cellular functions, and in turn, the cell devotes many genes/proteins to keep tight control of the level of intracellular free Ca2+. Here, we review recent work on Ca2+-dependent mechanisms and effectors that regulate the transcription of genes encoding proteins involved in the maintenance of the homeostasis of Ca2+ in the cell.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0021-9258
1083-351X
DOI:10.1074/jbc.R112.384982