Sensing of zinc ions and sulfide using a highly practical and water-soluble fluorescent sensor: applications in test kits and zebrafish

A novel practical fluorescent sensor AMPQ (2-((3-morpholinopropyl)amino)- N -((quinolin-8-yl)acetamide)) was designed and synthesized. In bis-tris buffer, AMPQ displayed highly practical and selective fluorescence recognition of Zn 2+ , clearly discriminating it from Cd 2+ and other cations. Moreove...

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Bibliographic Details
Published inNew journal of chemistry Vol. 44; no. 2; pp. 442 - 449
Main Authors Yun, Dongju, Chae, Ju Byeong, So, Haeri, Lee, Hyojin, Kim, Ki-Tae, Kim, Cheal
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 01.01.2020
Royal Society of Chemistry
Subjects
Chemistry
Chemistry, Multidisciplinary
Fluorescence
NMR
Nuclear magnetic resonance
Physical Sciences
Science & Technology
Selectivity
Sensors
Zebrafish
TURN-ON RESPONSE
SELECTIVE SENSOR
AQUEOUS-MEDIA
COLORIMETRIC SENSOR
SEQUENTIAL RECOGNITION
RELAY RECOGNITION
HYDROGEN-SULFIDE
CHEMO-SENSOR
LIVING CELLS
POTENTIOMETRIC SENSOR
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Summary:A novel practical fluorescent sensor AMPQ (2-((3-morpholinopropyl)amino)- N -((quinolin-8-yl)acetamide)) was designed and synthesized. In bis-tris buffer, AMPQ displayed highly practical and selective fluorescence recognition of Zn 2+ , clearly discriminating it from Cd 2+ and other cations. Moreover, the AMPQ -Zn 2+ complex exhibited a fluorescence "turn-off" response to S 2− with exceptional selectivity via a S 2− -induced Zn 2+ displacement approach. The detection limits (0.29 and 2.39 μM) of AMPQ for Zn 2+ and S 2− were much lower than the WHO guidelines (76.0 and 14.7 μM), respectively. Importantly, sensor AMPQ could be applied in various practical applications such as in real water samples and test kits. In particular, AMPQ could monitor both Zn 2+ and S 2− in live zebrafish, with a detection limit of 0.74 μM for Zn 2+ , which is the lowest among sensors previously reported for the relay detection of Zn 2+ and S 2− . The sensing process of AMPQ toward Zn 2+ and S 2− was evaluated by UV-vis and fluorescence spectroscopy, Job plots, ESI-MS, 1 H NMR titrations, and calculations. A practical fluorescent sensor was synthesized for recognition of Zn 2+ and S 2− and applied in various applications such as in live zebrafish.
Bibliography:10.1039/c9nj05057d
Electronic supplementary information (ESI) available. See DOI
ISSN:1144-0546
1369-9261
DOI:10.1039/c9nj05057d