Synthesis of a tetracyclic 2′-deoxyadenosine analog
A tetracyclic 2′-deoxyadenosine has been synthesized via a Stille biaryl coupling on a protected 6-chloro-7-deaza-7-iodopurine-2′-deoxyribose followed by cyclization. The nucleoside was incorporated into an oligodeoxynucleotide (ODN) and shown to pair with thymine. Graphic
Saved in:
Published in | Tetrahedron letters Vol. 40; no. 51; pp. 8969 - 8970 |
---|---|
Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
OXFORD
Elsevier Ltd
17.12.1999
Elsevier |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | A tetracyclic 2′-deoxyadenosine has been synthesized via a Stille biaryl coupling on a protected 6-chloro-7-deaza-7-iodopurine-2′-deoxyribose followed by cyclization. The nucleoside was incorporated into an oligodeoxynucleotide (ODN) and shown to pair with thymine.
Graphic |
---|---|
ISSN: | 0040-4039 1873-3581 |
DOI: | 10.1016/S0040-4039(99)01875-4 |