Attomolar analyte sensing techniques (AttoSens): a review on a decade of progress on chemical and biosensing nanoplatforms
Detecting the ultra-low abundance of analytes in real-life samples, such as biological fluids, water, soil, and food, requires the design and development of high-performance biosensing modalities. The breakthrough efforts from the scientific community have led to the realization of sensing technolog...
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| Published in | Chemical Society reviews Vol. 5; no. 23; pp. 1312 - 1389 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Royal Society of Chemistry
29.11.2021
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Detecting the ultra-low abundance of analytes in real-life samples, such as biological fluids, water, soil, and food, requires the design and development of high-performance biosensing modalities. The breakthrough efforts from the scientific community have led to the realization of sensing technologies that measure the analyte's ultra-trace level, with relevant sensitivity, selectivity, response time, and sampling efficiency, referred to as Attomolar Analyte Sensing Techniques (AttoSens) in this review. In an AttoSens platform, 1 aM detection corresponds to the quantification of 60 target analyte molecules in 100 μL of sample volume. Herein, we review the approaches listed for various sensor probe design, and their sensing strategies that paved the way for the detection of attomolar (aM: 10
−18
M) concentration of analytes. A summary of the technological advances made by the diverse AttoSens trends from the past decade is presented.
Attomolar analyte sensing in clinical diagnosis, food safety and environmental monitoring achieved by the technological advances in transducers design, bioreceptors functionalization and nanomaterials synthesis. |
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| Bibliography: | Dr Ruslan Álvarez Diduk obtained his PhD in Chemistry from the Universidad Autónoma Metropolitana (México) in 2014. From 2015 to date, he works as a postdoctoral researcher in the Nanobioelectronics and Biosensors group (Prof. Merkoçi). His research focuses on the development of novel nanostructured biosensors using both optical and electrochemical platforms, which are based on point-of-care and low-cost systems. He is also involved in exploring new and novel routes for nanoparticle synthesis, graphene reduction, and laser patterning, and the development of readout platforms including smartphone-based biosensing. Rehan Deshmukh is currently working as Assistant Professor at School of Biology, MIT World Peace University, India. He obtained his Masters in Microbiology from Pondicherry University in 2013 and PhD from the Biosensor Laboratory, Birla Institute of Technology and Science, Pilani, in the year 2020. He was awarded Senior Research Fellowship by the Indian Council of Medical Research, Government of India, in 2018. He worked as a research associate at the Biosensors Laboratory, IIT Madras. His research interests involve the development of electrochemical/optical biosensors for disease diagnosis and disease biomarker discovery. Hariharan Manoharan is currently working as a project scientist at the Biosensors Laboratory, Department of Applied Mechanics, IIT Madras, India. He received his PhD in the field of fiber optic biosensors from IIT Madras. He holds a master's degree in Chemical Engineering and Bachelor's degree in Pharmaceutical Technology from Anna University, Chennai. His research interests focus on clinical diagnostics, especially cancer detection. V. V. R. Sai received his PhD from Indian Institute of Technology (IIT) Bombay in 2009 for his work on U-bent fiber optic biosensors for biomolecules and pathogens. After a postdoctoral fellowship at University of Idaho, USA on SERS-based nucleic acid detection, he joined IIT Madras in 2011, where he is currently Associate Professor. His research focuses on the development of affordable technologies for clinical diagnostics, water, food, and environmental monitoring. He has authored 32 peer-reviewed research articles, and filed 1 US and 7 Indian patents. He received prestigious Young Engineer Award from Indian National Academy of Engineering (INAE) in 2015. Sruthi Prasood Usha obtained her Electronics and Communication Engineering degree from Kerala University in 2010 and Master of Technology in Optoelectronics and Laser Technology from CUSAT in 2013. She pursued her PhD at the Fiber Optic Sensors laboratory in IIT Delhi during 2014-2018. From 2018 to 2021, she worked as a post-doctoral fellow with the Biosensors Laboratory at IIT Madras. She is a recipient of the National Post-Doctoral Fellowship by DST, Government of India, 2019. Her research revolves around SPR-, LSPR-, and LMR-based fiber optic sensors using ZnO and MOF, and immunoassays for clinical diagnostics, and environmental and food safety. Arben Merkoçi is ICREA Professor and Director of the Nanobioelectronics & Biosensors Group at Institut Català de Nanociencia i Nanotecnologia, part of Barcelona Institute of Science and Technology. Prof. Merkoçi research is focused on the design and application of cutting edge nanotechnology and nanoscience-based biosensors. He has published around 310 peer review research papers, supervised 30 PhD students, and has been invited to give plenary/keynote lectures on about 200 occasions in various countries. He is Co-Editor In Chief of Biosensors and Bioelectronics and member and co-founder of two spin-off's, PaperDrop (for nanodiagnostics) and GraphenicaLab (for electronic printing). Enric Calucho (MSc, MRes) is a PhD student at the Nanobioelectronics and Biosensors Group of the Catalan Institute of Nanoscience and Nanotechnology (ICN2) under the supervision of Prof. Arben Merkoçi and Dr Ruslan Álvarez-Diduk. Enric carried out two Master theses in the same institution. In 2017, he finished a Master's degree in Advanced Nanoscience and Nanotechnology (UAB) and in 2018, a Master's degree in Multidisciplinary Research in Experimental Sciences in the Barcelona Institute of Science and Technology (BIST). His line of research focuses on the integration of graphene-related materials and other nanomaterials into optical and electrochemical paper-based biosensors in order to find strategies to enhance their sensitivity. ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
| ISSN: | 0306-0012 1460-4744 |
| DOI: | 10.1039/d1cs00137j |