Synthesis, characterisation and multi-modal intracellular mapping of cisplatin nano-conjugates

The synthesis of nanocarriers for the delivery of the antitumor drug cisplatin is reported. Multimodal-imaging consisting of surface enhanced Raman scattering and laser ablation inductively coupled plasma time of flight mass spectrometry was used to visualise the intracellular uptake of both the nan...

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 59; no. 42; pp. 6395 - 6398
Main Authors Leventi, Aristea Anna, Braddick, Henry J, Billimoria, Kharmen, Wallace, Gregory Q, Goenaga-Infante, Heidi, Tomkinson, Nicholas C.O, Faulds, Karen, Graham, Duncan
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 23.05.2023
Subjects
Antineoplastic Agents
Biological Transport
Cisplatin
Inductively coupled plasma
Laser ablation
Mass spectrometry
Raman spectra
Spectrum Analysis, Raman
Synthesis
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Summary:The synthesis of nanocarriers for the delivery of the antitumor drug cisplatin is reported. Multimodal-imaging consisting of surface enhanced Raman scattering and laser ablation inductively coupled plasma time of flight mass spectrometry was used to visualise the intracellular uptake of both the nanocarrier and drug. A multimodal imaging platform can ascertain the spatial resolution and intracellular uptake of both the nanocarrier and drug as unique species.
Bibliography:https://doi.org/10.1039/d3cc00925d
Electronic supplementary information (ESI) available. See DOI
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1359-7345
1364-548X
DOI:10.1039/d3cc00925d