Photodynamic therapy for nasal and aural squamous cell carcinoma in cats

• Published in: Journal of the American Veterinary Medical Association Vol. 202; no. 8; p. 1261
• Main Authors: Peaston, A.E. (University of California, Davis, CA), Leach, M.W, Higgins, R.J
• Format: Journal Article
• Language: English
• Published: United States 15.04.1993
• Subjects: ADVERSE EFFECTS; aluminum phthalocyanine tetrasulfhonate; Animals; CARCINOMA; Carcinoma, Squamous Cell - drug therapy; Carcinoma, Squamous Cell - veterinary; CARCINOME; Cat Diseases - drug therapy; CATS; CHAT; Ear Neoplasms - drug therapy; Ear Neoplasms - veterinary; Ear, External; EARS; EFECTOS SECUNDARIOS; EFFET SECONDAIRE; Female; FOTOSENSIBILIDAD; GATO; Indoles - therapeutic use; LIGHT; LUMIERE; LUZ; Male; NARIZ; NEZ; NOSE; Nose Neoplasms - drug therapy; Nose Neoplasms - veterinary; OREILLE; OREJAS; Organometallic Compounds - therapeutic use; PATHOGENESE; PATHOGENESIS; PATOGENESIS; Photochemotherapy - adverse effects; Photochemotherapy - veterinary; PHOTOSENSIBILITE; PHOTOSENSITIVITY; PHOTOSENSITIZATION; Photosensitizing Agents - therapeutic use; PHOTOTHERAPY; PROGNOSIS; SIDE EFFECTS; TERAPIA; THERAPEUTIQUE; THERAPY; Treatment Outcome
• ISSN: 0003-1488; 1943-569X
• DOI: 10.2460/javma.1993.202.08.1261

Eighteen random-bred cats with a total of 19 nasal or aural squamous cell carcinomas were treated with photodynamic therapy, using aluminum phthalocyanine tetrasulfonate as the photosensitizer. Cats were irradiated at power densities of 100 mW/cm2 and energy densities of 100 J/cm2. Successful outcome was obtained in 10 tumors after 1 treatment, and 2 more tumors had complete responses after 1 or 2 additional treatments. Treatments were more effective in tumors of stage T2 or earlier. Five tumors had partial responses, and the response of 2 tumors could not be evaluated. The treatment was safe and well tolerated by most cats, although we found that cats should be kept out of sunlight for 2 weeks after treatment.