Experimental studies of the effect of bupivacaine on peripheral nerves

0.5% Bupivacaine was administered around the sciatic nerve of rabbits by means of a catheter, over a period of ten days. Twenty nerves showed no histological changes, but in three there were areas of demyelination and axonal degeneration, especially near the surface of the nerve. However, similar ch...

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Bibliographic Details
Published inJournal of hand surgery, British volume Vol. 12; no. 1; pp. 19 - 22
Main Authors Helm, R.H., Lee, Y.S., Pho, R.W.H.
Format Journal Article
LanguageEnglish
Published Edinburgh Elsevier Ltd 01.02.1987
Churchill Livingstone
Subjects
Anesthetics. Neuromuscular blocking agents
Animals
Axons - drug effects
Biological and medical sciences
Bupivacaine - toxicity
Catheterization - adverse effects
Demyelinating Diseases - chemically induced
Medical sciences
Nerve Degeneration - drug effects
Neuropharmacology
Pharmacology. Drug treatments
Rabbits
Sciatic Nerve - drug effects
Rabbit
Peripheral nerve
Vertebrata
Mammalia
Lagomorpha
Toxicity
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Summary:0.5% Bupivacaine was administered around the sciatic nerve of rabbits by means of a catheter, over a period of ten days. Twenty nerves showed no histological changes, but in three there were areas of demyelination and axonal degeneration, especially near the surface of the nerve. However, similar changes occurred in two out of six nerves to which normal saline was administered instead, and it is suggested that the damage may have been caused by mechanical trauma from movement of the catheter.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0266-7681
1532-2211
DOI:10.1016/0266-7681(87)90046-5