Insertion/Deletion Polymorphism of the Angiotensin Converting Enzyme Gene in Coronary Artery Disease in Southern Turkey

• Published in: BMB reports Vol. 38; no. 4; pp. 486 - 490
• Main Authors: Acarturk, Esmeray (Cukurova University, Adana, Turkey), E-mail: kanarya@cu.edu.tr, Attila, Gulen (Cukurova University, Adana, Turkey), Bozkurt, Abdi (Cukurova University, Adana, Turkey), Akpmar, Onur (Cukurova University, Adana, Turkey), Matyar, Selcuk (Cukurova University, Adana, Turkey), Seydaoglu, Gulsah (Cukurova University, Adana, Turkey)
• Format: Journal Article
• Language: English
• Published: Korea (South) 31.07.2005
• Subjects: ACE; Adult; Aged; Aged, 80 and over; Allele; Alleles; Coronary Angiography; Coronary artery disease; Coronary Artery Disease - blood; Coronary Artery Disease - enzymology; Coronary Artery Disease - genetics; Female; GENE; Gene Deletion; Gene Frequency; Gene polymorphism; GENES; Genotype; Humans; Male; Middle Aged; Peptidyl-Dipeptidase A - blood; Peptidyl-Dipeptidase A - genetics; Polymorphism, Genetic; Risk Factors; Southern Turkey; Turkey - epidemiology; Turkey
• ISSN: 1225-8687; 1976-6696; 0219-1024
• DOI: 10.5483/bmbrep.2005.38.4.486

Genetic factors are important in the pathogenesis of coronary artery disease (CAD). Angiotensin converting enzyme (ACE) gene insertion(I)/deletion(D) polymorphism is one of the genetic factor found to be related with CAD. We investigated the association between I/D polymorphism of the ACE gene and the presence of CAD. Threehundred and seven patients (187 males and 120 females, aged between 35-80, mean 54.3±9.8 years) who underwent diagnostic coronary angiography were included in the study. ACE I/D polymorphism was detected by polymerase chain reaction. Of the 307, 176 had CAD. The most frequently observed genotype in all subjects was ID (47.9 %).