Soluble transferrin receptor and transferrin receptor-ferritin index in iron deficiency anemia and anemia in rheumatoid arthritis

• Published in: Clinical chemistry and laboratory medicine Vol. 43; no. 3; pp. 326 - 331
• Main Authors: Margetic, Sandra, Topic, Elizabeta, Ferenec Ruzic, Dragica, Kvaternik, Marina
• Format: Journal Article
• Language: English
• Published: Berlin De Gruyter 01.01.2005; New York, NY Walter de Gruyter
• Subjects: Adolescent; Adult; Aged; Anemia - blood; Anemia - complications; Anemia - diagnosis; anemia in rheumatoid arthritis; Anemia, Iron-Deficiency - blood; Anemia, Iron-Deficiency - diagnosis; Arthritis, Rheumatoid - blood; Arthritis, Rheumatoid - complications; Biological and medical sciences; Body Mass Index; C-Reactive Protein - metabolism; Female; Ferritins - blood; General aspects; Humans; Investigative techniques, diagnostic techniques (general aspects); Iron - blood; Iron - deficiency; iron deficiency anemia; Male; Medical sciences; Middle Aged; Prospective Studies; Receptors, Transferrin - blood; ROC Curve; Sensitivity and Specificity; Solubility; soluble transferrin receptor; transferrin receptor-ferritin index; Iron deficiency anemia; Diseases of the osteoarticular system; Ferritin; Autoimmune disease; Metabolic diseases; Hemopathy; Inflammatory joint disease; Iron; Index; Soluble form; Enzymopathy; Inorganic element; Transferrin receptor; Medicine; transferrin receptor-ferritin index; anemia in rheumatoid arthritis; Chronic; soluble transferrin receptor; Rheumatoid arthritis; Clinical biology; Dosage form; Sideropenia
• ISSN: 1434-6621; 1437-4331
• DOI: 10.1515/CCLM.2005.056

The aim of the study was to evaluate the clinical efficiency of soluble transferrin receptor and transferrin receptor-ferritin index (sTfR/logF) in the diagnosis of iron deficiency anemia, as well as the differential diagnosis of iron deficiency anemia and anemia in rheumatoid arthritis. The study included 96 patients with anemia and 61 healthy volunteers as a control group. In healthy subjects there were no significant sex and age differences in the parameters tested. The study results showed these parameters to be reliable in the diagnosis of iron deficiency anemia, as well as in the differential diagnosis of iron deficiency anemia and anemia of chronic disease. The results indicate that sTfR/logF could be used to help differentiate coexisting iron deficiency in patients with anemia of chronic disease. Receiver operating characteristic analysis showed a higher discriminating power of transferrin receptor-ferritin index vs. soluble transferrin receptor in the diagnosis of iron deficiency anemia, as well as in the differential diagnosis between iron deficiency anemia and anemia of chronic disease. In patients with anemia in rheumatoid arthritis, the parameters tested showed no significant differences with respect to C-reactive protein concentration. These results suggested that the parameters tested are not affected by acute or chronic inflammatory disease.