Ocular blastomycosis in dogs: 73 cases, 108 eyes (1985-1993)

• Published in: Journal of the American Veterinary Medical Association Vol. 209; no. 7; p. 1271
• Main Authors: Bloom, J.D. (Willowdale Animal Hospital, North York, Ontario, Canada.), Hamor, R.E, Gerding, P.A. Jr
• Format: Journal Article
• Language: English
• Published: United States 01.10.1996
• Subjects: AMPHOTERICIN B; Amphotericin B - administration & dosage; Amphotericin B - therapeutic use; Animals; Antifungal Agents - administration & dosage; Antifungal Agents - therapeutic use; ASSOCIATION MEDICAMENTEUSE; Blastomycosis - drug therapy; Blastomycosis - pathology; Blastomycosis - veterinary; CHIEN; Dog Diseases - drug therapy; Dog Diseases - pathology; DOGS; DRUG COMBINATIONS; DRUG THERAPY; Drug Therapy, Combination; DRUGS; ENFERMEDADES DE LOS OJOS; Eye - pathology; EYE DISEASES; Eye Infections, Fungal - drug therapy; Eye Infections, Fungal - pathology; Eye Infections, Fungal - veterinary; Female; FONGICIDE; FUNGICIDAS; FUNGICIDES; KETOCONAZOLE; Ketoconazole - administration & dosage; Ketoconazole - therapeutic use; MALADIE DE L'OEIL; Male; MEDICAMENT; MEDICAMENTOS; MEZCLA DE MEDICAMENTOS; MICOSIS; MYCOSE; MYCOSES; PATHOGENESE; PATHOGENESIS; PATOGENESIS; PERRO; PROGNOSIS; Retrospective Studies; SINTOMAS; SYMPTOME; SYMPTOMS; TERAPEUTICA MEDICAMENTOSA; THERAPEUTIQUE MEDICAMENTEUSE; Treatment Outcome
• ISSN: 0003-1488; 1943-569X
• DOI: 10.2460/javma.1996.209.07.1271

To evaluate clinical signs of ocular blastomycosis in dogs, to determine response of blastomycosis-infected eyes to treatment with systemically administered amphotericin B and ketoconazole, and to identify prognostic indicators of successful antifungal treatment. Retrospective study. 73 dogs. Medical records were reviewed for all dogs with confirmed blastomycosis and ocular disease seen at our hospital between 1985 and 1993. 6 eyes had anterior segment disease, 24 had posterior segment disease, and 78 had endophthalmitis. 40 eyes were treated with a combination of amphotericin B and ketoconazole, and 16 of the 40 responded favorably. However, 16 of the 24 eyes that were not severely affected responded favorably, but none of the 16 eyes that were severely affected did. Dogs with blastomycosis had posterior segment disease, without complete retinal separation, had a good prognosis for retaining vision. Results of histologic examination suggested that secondary glaucoma was a manifestation of endophthalmitis and was indicative of a grave prognosis for response to antifungal and antiglaucoma treatment.