Synergy and sensitivity-balance in concatenating experiments in NO relaxation delay NMR (NORD)

The NMR experiment design strategy of NO Relaxation Delay (NORD), introduced mostly as an idealized theoretical approach, is extended and put to practical use by considering synergy and sensitivity-balance in concatenation of experiments. It is illustrated by a novel experiment, NORD {HMBC}-{HSQC}-{...

Full description

Saved in:
Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 58; no. 15; pp. 2516 - 2519
Main Authors Timári, István, Nagy, Tamás Milán, Kövér, Katalin E, Sørensen, Ole W
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 17.02.2022
Subjects
Carbohydrates
Carbon Isotopes
Design of experiments
Experiments
Magnetic Resonance Spectroscopy
Nitric Oxide - analysis
NMR
Nuclear magnetic resonance
Peptides
Sensitivity
Online AccessGet full text

Cover

More Information
Summary:The NMR experiment design strategy of NO Relaxation Delay (NORD), introduced mostly as an idealized theoretical approach, is extended and put to practical use by considering synergy and sensitivity-balance in concatenation of experiments. It is illustrated by a novel experiment, NORD {HMBC}-{HSQC}-{TOCSY}, where magnetization of non- 13 C attached protons effectively is channeled from the TOCSY spectrum toward primarily the least sensitive spectrum of HMBC. The experiment is expected to find its place as a full-package NMR method for metabolomics, carbohydrates, peptides and small-molecules in general. The NMR experiment design strategy of NO Relaxation Delay (NORD), introduced mostly as an idealized theoretical approach, is extended and put to practical use by considering synergy and sensitivity-balance in concatenation of experiments.
Bibliography:10.1039/d1cc06663c
Electronic supplementary information (ESI) available. See DOI
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1359-7345
1364-548X
DOI:10.1039/d1cc06663c