A concise synthesis of the HIV-protease inhibitor nelfinavir via an unusual tetrahydrofuran rearrangement
An efficient synthesis of nelfinavir 1 was developed. The synthesis features an unusual rearrangement of a 3-amidotetrahydrofuran into a functionalized oxazoline.
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Published in | Tetrahedron letters Vol. 41; no. 36; pp. 7017 - 7021 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
OXFORD
Elsevier Ltd
02.09.2000
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | An efficient synthesis of nelfinavir
1 was developed. The synthesis features an unusual rearrangement of a 3-amidotetrahydrofuran into a functionalized oxazoline. |
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ISSN: | 0040-4039 1873-3581 |
DOI: | 10.1016/S0040-4039(00)01231-4 |