A concise synthesis of the HIV-protease inhibitor nelfinavir via an unusual tetrahydrofuran rearrangement

An efficient synthesis of nelfinavir 1 was developed. The synthesis features an unusual rearrangement of a 3-amidotetrahydrofuran into a functionalized oxazoline.

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Bibliographic Details
Published inTetrahedron letters Vol. 41; no. 36; pp. 7017 - 7021
Main Authors Zook, Scott E, Busse, Juliette K, Borer, Bennett C
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 02.09.2000
Elsevier
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
PRACTICAL SYNTHESIS
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Summary:An efficient synthesis of nelfinavir 1 was developed. The synthesis features an unusual rearrangement of a 3-amidotetrahydrofuran into a functionalized oxazoline.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(00)01231-4