Direct activation of the ion channel TRPA1 by Ca2

TRPA1 is an ion channel expressed by nociceptors and activated by irritant compounds such as mustard oil. The endogenous function of TRPA1 has remained unclear, a fact highlighted by ongoing debate over its potential role as a sensor of noxious cold. Here we show that intracellular Ca(2+) activates...

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Bibliographic Details
Published inNature neuroscience Vol. 10; no. 3; pp. 277 - 279
Main Authors Zurborg, Sandra, Yurgionas, Brian, Jira, Julia A, Caspani, Ombretta, Heppenstall, Paul A
Format Journal Article
LanguageEnglish
Published United States Nature Publishing Group 01.03.2007
Subjects
Analgesics, Non-Narcotic - pharmacology
Calcium - metabolism
Calcium channels
Calcium Channels - physiology
Calcium ions
Carbachol - pharmacology
Cell Line
Cold Temperature
Diagnostic Imaging - methods
Dose-Response Relationship, Drug
EF Hand Motifs - physiology
Genetic aspects
Humans
Intracellular Fluid - metabolism
Luminescent Proteins - metabolism
Membrane Proteins - physiology
Mutagenesis - physiology
Nerve Tissue Proteins - physiology
Patch-Clamp Techniques - methods
Physiological aspects
Physiology
Transfection - methods
Transient Receptor Potential Channels - drug effects
Transient Receptor Potential Channels - physiology
Transient Receptor Potential Channels - radiation effects
TRPA1 Cation Channel
Germany
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Summary:TRPA1 is an ion channel expressed by nociceptors and activated by irritant compounds such as mustard oil. The endogenous function of TRPA1 has remained unclear, a fact highlighted by ongoing debate over its potential role as a sensor of noxious cold. Here we show that intracellular Ca(2+) activates human TRPA1 via an EF-hand domain and that cold sensitivity occurs indirectly (and nonphysiologically) through increased [Ca(2+)](i) during cooling in heterologous systems.
ISSN:1097-6256
1546-1726
DOI:10.1038/nn1843