A novel and efficient arylation of malononitrile catalyzed by nickel(0) complexes
We report the first use of a nickel catalyst for the direct arylation of a β-difunctionalized compound, the malononitrile, from halogenated aromatic substrates. The catalytic system is quite simple: Ni(PPh 3) 3, generated in situ from NiBr 2(PPh 3) 2, PPh 3 and zinc. Good yields and excellent select...
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Published in | Tetrahedron letters Vol. 41; no. 44; pp. 8457 - 8460 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
OXFORD
Elsevier Ltd
28.10.2000
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | We report the first use of a nickel catalyst for the direct arylation of a β-difunctionalized compound, the malononitrile, from halogenated aromatic substrates. The catalytic system is quite simple: Ni(PPh
3)
3, generated in situ from NiBr
2(PPh
3)
2, PPh
3 and zinc. Good yields and excellent selectivities have been obtained in α-arylmalononitriles from iodobenzene, but also from bromo- or chloro-aromatic substrates. |
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ISSN: | 0040-4039 1873-3581 |
DOI: | 10.1016/S0040-4039(00)01500-8 |