Solid-phase synthesis of tertiary methylamines via reductive alkylation–fragmentation using a hydroxylamine linker

The solid-phase synthesis of tertiary methylamines via reductive alkylation–fragmentation employing a hydroxylamine linker is described. The hydroxylamine linker is traceless, robust and versatile, allowing strong organometallic reagents to be used in the synthesis of diverse tertiary methylamines....

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Bibliographic Details
Published inTetrahedron letters Vol. 41; no. 34; pp. 6635 - 6638
Main Authors Blaney, Paul, Grigg, Ronald, Rankovic, Zoran, Thoroughgood, Matthew
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 19.08.2000
Elsevier
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
solid-phase synthesis
tertiary methylamines
traceless hydroxylamine linker
solid-phase synthesis
tertiary methylamines
traceless hydroxylamine linker
ORGANIC-SYNTHESIS
REM RESIN
AMINES
CHEMISTRY
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Summary:The solid-phase synthesis of tertiary methylamines via reductive alkylation–fragmentation employing a hydroxylamine linker is described. The hydroxylamine linker is traceless, robust and versatile, allowing strong organometallic reagents to be used in the synthesis of diverse tertiary methylamines.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(00)01103-5