Vaginal Stenosis After Gonadotropin-Releasing Hormone Agonist Therapy During Treatment for Acute Lymphoblastic Leukemia

A 26-year-old patient with a history of chemotherapy for acute lymphoblastic leukemia presented with secondary amenorrhea and cyclic abdominal pain, and she was found to have vaginal stenosis due to adhesion of vaginal wall. The cause of the adhesion was considered to be vaginal inflammation induced...

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Published inJournal of lower genital tract disease Vol. 20; no. 2; p. e11
Main Authors Sato, Masakazu, Harada, Miyuki, Oishi, Hajime, Wada-Hiraike, Osamu, Hirata, Tetsuya, Nagasaka, Kazunori, Koga, Kaori, Fujii, Tomoyuki, Osuga, Yutaka
Format Journal Article
LanguageEnglish
Published United States 01.04.2016
Subjects
Adult
Antineoplastic Agents, Hormonal - adverse effects
Antineoplastic Agents, Hormonal - therapeutic use
Constriction, Pathologic - chemically induced
Constriction, Pathologic - pathology
Female
Humans
Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy
Vaginal Diseases - chemically induced
Vaginal Diseases - pathology
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Summary:A 26-year-old patient with a history of chemotherapy for acute lymphoblastic leukemia presented with secondary amenorrhea and cyclic abdominal pain, and she was found to have vaginal stenosis due to adhesion of vaginal wall. The cause of the adhesion was considered to be vaginal inflammation induced by anticancer agents themselves. It was also considered that poor estrogenization of vaginal mucosa as a result of gonadotropin-releasing hormone agonist therapy, conducted for ovarian protection during chemotherapy, might have exacerbated it. Because it is more likely than ever for us to encounter patients who will undertake or had undertaken chemotherapy with gonadotropin-releasing hormone agonist therapy, keen observation and proper intervention would be important.
ISSN:1526-0976
DOI:10.1097/lgt.0000000000000175