Chemical characterization of bioactive compounds from the endophytic fungus Diaporthe helianthi isolated from Luehea divaricata

Endophytic microorganisms, defined as fungi or bacteria that colonize the interior of plants without causing any immediate negative effects or damages, have reciprocal relationships with host plants. In some cases their presence is beneficial to the host due to the synthesis of bioactive compounds,...

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Bibliographic Details
Published inBrazilian journal of microbiology Vol. 43; no. 3; pp. 1174 - 1182
Main Authors Specian, Vânia, Sarragiotto, Maria Helena, Pamphile, João Alencar, Clemente, Edmar
Format Journal Article
LanguageEnglish
Published São Paulo Springer Nature B.V 01.07.2012
Sociedade Brasileira de Microbiologia
Subjects
Bacteria
Fungi
Metabolites
MICROBIOLOGY
Microorganisms
phenolic compound
Diaporthe helianthi
endophytic fungi
Tyrosol
secondary metabolite
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Summary:Endophytic microorganisms, defined as fungi or bacteria that colonize the interior of plants without causing any immediate negative effects or damages, have reciprocal relationships with host plants. In some cases their presence is beneficial to the host due to the synthesis of bioactive compounds, among which several alcohols, esters, ketones and others that may react with other compounds and may be lethal to pathogenic microorganisms. Diaporthe helianthi (Phomopsis helianthi in its anamorphic phase) is available worldwide, especially in Europe, Asia and America. Isolated in Europe as an agent of the sunflower stem cancer, it has also been endophytically isolated from tropical and temperate plants. A D. helianthi strain isolated from Luehea divaricata has been employed in current research. An investigation of the secondary metabolite from D. helianthi by CC and NMR of 1H and 13C yielded the separation of 10 fractions and the identification of the phenolic compound 2(-4 hydroxyphenyl)-ethanol (Tyrosol). Its antimicrobial reaction was tested and the ensuing antagonistic effects on the human pathogenic bacteria Enterococcus hirae, Escherichia coli, Micrococcus luteus, Salmonella typhi, Staphylococcus aureus, phytopathogenic Xanthomonas asc. phaseoli and phytopathogenic fungi were demonstrated. Results show that bioactive compounds and Tyrosol produced by D. helianthi have a biotechnological potential. [PUBLICATION ABSTRACT]
ISSN:1517-8382
1678-4405
1678-4405
DOI:10.1590/S1517-83822012000300045