Network-motif delay differential analysis of brain activity during seizures

Delay Differential Analysis (DDA) is a nonlinear method for analyzing time series based on principles from nonlinear dynamical systems. DDA is extended here to incorporate network aspects to improve the dynamical characterization of complex systems. To demonstrate its effectiveness, DDA with network...

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Bibliographic Details
Published inChaos (Woodbury, N.Y.) Vol. 33; no. 12
Main Authors Lainscsek, Claudia, Salami, Pariya, Carvalho, Vinícius Rezende, Mendes, Eduardo M A M, Fan, Miaolin, Cash, Sydney S, Sejnowski, Terrence J
Format Journal Article
LanguageEnglish
Published United States 01.12.2023
Subjects
Brain
Electrocorticography - methods
Electroencephalography - methods
Humans
Nonlinear Dynamics
Seizures
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Summary:Delay Differential Analysis (DDA) is a nonlinear method for analyzing time series based on principles from nonlinear dynamical systems. DDA is extended here to incorporate network aspects to improve the dynamical characterization of complex systems. To demonstrate its effectiveness, DDA with network capabilities was first applied to the well-known Rössler system under different parameter regimes and noise conditions. Network-motif DDA, based on cortical regions, was then applied to invasive intracranial electroencephalographic data from drug-resistant epilepsy patients undergoing presurgical monitoring. The directional network motifs between brain areas that emerge from this analysis change dramatically before, during, and after seizures. Neural systems provide a rich source of complex data, arising from varying internal states generated by network interactions.
ISSN:1089-7682
DOI:10.1063/5.0165904