Mucosal lesions of the upper gastrointestinal tract in patients with ulcerative colitis: A review

Ulcerative colitis (UC) is a chronic, nonspecific, relapsing inflammatory bowel disease. The colorectum is considered the chief target organ of UC, whereas upper gastrointestinal (UGI) tract manifestations are infrequent. Recently, emerging evidence has suggested that UC presents complications in es...

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Published inWorld journal of gastroenterology : WJG Vol. 27; no. 22; pp. 2963 - 2978
Main Authors Sun, Yan, Zhang, Zhe, Zheng, Chang-Qing, Sang, Li-Xuan
Format Journal Article
LanguageEnglish
Published Baishideng Publishing Group Inc 14.06.2021
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Review
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Summary:Ulcerative colitis (UC) is a chronic, nonspecific, relapsing inflammatory bowel disease. The colorectum is considered the chief target organ of UC, whereas upper gastrointestinal (UGI) tract manifestations are infrequent. Recently, emerging evidence has suggested that UC presents complications in esophageal, stomachic, and duodenal mucosal injuries. However, UC-related UGI tract manifestations are varied and frequently silenced or concealed. Moreover, the endoscopic and microscopic characteristics of UGI tract complicated with UC are nonspecific. Therefore, UGI involvement may be ignored by many clinicians. In addition, no standard criteria have been established for patients with UC who should undergo fibrogastroduodenoscopy. Furthermore, specific treatment recommendations may be needed for patients with UC-associated UGI lesions. Herein, we review the esophageal, gastric, and duodenal mucosal lesions of the UC-associated UGI tract, as well as the potential pathogenesis and therapy.
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Corresponding author: Li-Xuan Sang, MD, PhD, Associate Professor, Doctor, Department of Gastroenterology, Shengjing Hospital of China Medical University, No. 39 Huaxiang Road, Tiexi District, Shenyang 110022, Liaoning Province, China. sanglixuan2008@163.com
Author contributions: Sun Y and Sang LX designed and performed the research; Sun Y, Zhang Z, Zheng CQ, and Sang LX contributed to the analysis and review; Sun Y wrote the paper; Sang LX revised the paper.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v27.i22.2963