Pyridinium salts: from synthesis to reactivity and applications

Structurally diverse pyridinium salts are quite familiar structures in many natural products and bioactive pharmaceuticals. Over the centuries, these privileged scaffolds have played an intriguing role in a wide range of research topics and, thus, this review aims at highlighting the pyridinium salt...

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Published inOrganic chemistry frontiers an international journal of organic chemistry Vol. 5; no. 3; pp. 453 - 493
Main Authors Subbiah Sowmiah, José M S S Esperança, Rebelo, Luís P N, Afonso, Carlos A M
Format Journal Article
LanguageEnglish
Published London Royal Society of Chemistry 01.01.2018
Subjects
Antiinfectives and antibacterials
Biological materials
Cancer
Cholinesterase
Cholinesterase inhibitors
Gene transfer
Ionic liquids
Materials science
Microorganisms
Natural products
Organic chemistry
Pyridinium
Salts
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Summary:Structurally diverse pyridinium salts are quite familiar structures in many natural products and bioactive pharmaceuticals. Over the centuries, these privileged scaffolds have played an intriguing role in a wide range of research topics and, thus, this review aims at highlighting the pyridinium salts in terms of their synthetic routes, reactivity and their importance as pyridinium ionic liquids, as pyridinium ylides, as anti-microbial, anti-cancer, anti-malarial and anti-cholinesterase inhibitors, as well as their applications in materials science and biological issues related to gene delivery.
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ISSN:2052-4110
2052-4110
DOI:10.1039/c7qo00836h