Incorporating zeolitic-imidazolate framework-8 nanoparticles into kidney scaffolds: a first step towards innovative renal therapies

We demonstrate for the first time the potential of zeolitic-imidazolate framework-8 nanoparticles to be incorporated within a renal scaffold while retaining their ability to remove uremic toxins (mainly hydrophobic toxins like p -cresol) under flow conditions. This work may pave the way for the futu...

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Published inNanoscale Vol. 14; no. 47; pp. 17543 - 17549
Main Authors Guerrero, Fátima, Pulido, Victoria, Hamad, Said, Aljama, Pedro, Martín-Malo, Alejandro, Carrillo-Carrión, Carolina
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 08.12.2022
Subjects
Artificial kidneys
Kidneys
Metal-organic frameworks
Nanoparticles
Scaffolds
Toxins
Zeolites
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Summary:We demonstrate for the first time the potential of zeolitic-imidazolate framework-8 nanoparticles to be incorporated within a renal scaffold while retaining their ability to remove uremic toxins (mainly hydrophobic toxins like p -cresol) under flow conditions. This work may pave the way for the future development of novel adsorbents for dialysis and/or artificial kidneys. We demonstrate the successful immobilization of polymer-stabilized ZIF-8 nanoparticles within a kidney scaffold, endowing it with a high adsorption capacity to remove uremic toxins (mainly hydrophobic ones) under flow conditions.
Bibliography:https://doi.org/10.1039/d2nr04246k
Electronic supplementary information (ESI) available. See DOI
Carolina Carrillo-Carrión is currently a Tenured Scientist at the Institute for Chemical Research (IIQ, CSIC-University of Seville). She received her Ph.D. from the University of Córdoba (2011). Then she worked at different universities and research centres: Philipps-Universität Marburg (Germany, as a Humboldt), CICbiomaGUNE (San Sebastián, as a JdC-I researcher), CiQUS-University Santiago de Compostela (as a Marie Curie fellow), University of Córdoba (PI of a national project for young researchers), and University of Seville (as a Ramón y Cajal researcher). Nowadays, her research is focused on developing multifunctional metal-organic frameworks for applications in the biomedical and (bio)catalytic fields.
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ISSN:2040-3364
2040-3372
DOI:10.1039/d2nr04246k