Studies on Development of Sufficiently Chemoselective N-Acylation Reagents: N-Acyl- N-(2,3,4,5,6-pentafluorophenyl)methanesulfonamides

A variety of storable N-acyl- N-(2,3,4,5,6-pentafluorophenyl)methanesulfonamides ( 4a– e) prepared from N-2,3,4,5,6-pentafluorophenylmethanesulfonamide ( 3), have been developed after systematic research on the structure–reactivity relationship and were found to serve as N-acylation reagents exhibit...

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Bibliographic Details
Published inTetrahedron Vol. 56; no. 32; pp. 5843 - 5856
Main Authors Kondo, Kazuhiro, Sekimoto, Erika, Nakao, Junko, Murakami, Yasuoki
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 04.08.2000
Elsevier
Subjects
alkoxycarbonylation
amine
Chemistry
Chemistry, Organic
chemoselective N-acylation reagent
Physical Sciences
protective group
Science & Technology
sulfonamide
alkoxycarbonylation
chemoselective N-acylation reagent
protective group
sulfonamide
amine
ALCOHOLS
PRIMARY AMINO-GROUPS
TRIFLUOROACETYLATING REAGENT
LEAVING GROUP
FACILE
SPERMIDINE
AMIDES
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Summary:A variety of storable N-acyl- N-(2,3,4,5,6-pentafluorophenyl)methanesulfonamides ( 4a– e) prepared from N-2,3,4,5,6-pentafluorophenylmethanesulfonamide ( 3), have been developed after systematic research on the structure–reactivity relationship and were found to serve as N-acylation reagents exhibiting sufficiently good chemoselectivity.
ISSN:0040-4020
1464-5416
DOI:10.1016/S0040-4020(00)00549-4