Low generation PEGylated phosphorus-containing dendrons with phosphonate anchors

• Published in: Tetrahedron letters Vol. 53; no. 15; pp. 1908 - 1911
• Main Authors: Barrière, Clément, Latour, Virginie, Fau, Pierre, Caminade, Anne-Marie, Turrin, Cédric-Olivier
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 11.04.2012; Elsevier
• Subjects: Adhesives; Chemical Sciences; Coordination chemistry; Dendrimer; Mathematical models; PEG; Phosphonate; Phosphonates; Polyethylene glycol; Silicon; Strategy; Surface chemistry; Tetrahedrons; Phosphonate; Dendrimer; PEG
• ISSN: 0040-4039; 1873-3581
• DOI: 10.1016/j.tetlet.2012.01.138

We present a simple strategy to obtain non-symmetrical polyethylene glycols equipped with telechelic phosphorus-containing dendrimeric moieties having adhesive phosphonate surface functions. The dendronized PEG tails were characterized by means of multi-nucleus NMR. The grafting abilities of model symmetrical PEG compounds equipped with telechelic amino-bis(methylene dimethylphosphonates) and amino-bis(methylenephosphonic acids) were rapidly screened on plasma treated silicon wafers and activated silica. We present a simple strategy to obtain non-symmetrical polyethylene glycols equipped with telechelic phosphorus-containing dendrimeric moieties having adhesive phosphonate surface functions. The dendronized PEG tails were characterized by means of multi-nucleus NMR. The grafting abilities of model symmetrical PEG compounds equipped with telechelic amino-bis(methylene-dimethylphosphonates) and amino-bis(methylenephosphonic acids) were rapidly screened on plasma treated silicon wafers and activated silica.