Terpeptin, a novel mammalian cell cycle inhibitor, produced by Aspergillus terreus 95F-1

Terpeptin, a novel peptide having cell cycle inhibitory activity, was isolated from the cultured broth of Aspergillus terreus 95F-1 and its structure was elucidated by spectral analyses. Terpeptin inhibited the cell cycle progression of mouse tsFT210 cells in the G2/M phase with a minimum inhibitory...

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Published inTetrahedron letters Vol. 38; no. 7; pp. 1223 - 1226
Main Authors Kagamizono, Terumi, Sakai, Noriyoshi, Arai, Koshi, Kobinata, Kimie, Osada, Hiroyuki
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 17.02.1997
Elsevier
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
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Summary:Terpeptin, a novel peptide having cell cycle inhibitory activity, was isolated from the cultured broth of Aspergillus terreus 95F-1 and its structure was elucidated by spectral analyses. Terpeptin inhibited the cell cycle progression of mouse tsFT210 cells in the G2/M phase with a minimum inhibitory concentration of 62.5 μM. Terpeptin, a novel cell cycle inhibitor, was isolated from the cultured broth of Aspergillus terreus 95F-1. The structure was elucidated by spectral analyses. Terpeptin showed an inhibitory activity on the cell cycle progression of mouse tsFT210 cells in the C2/M phase.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(97)00022-1