Infectious mononucleosis – should we routinely assess liver function in acute presentation and follow up?

Infectious mononucleosis is a relatively common acute presentation to the ENT department. There is an expected derangement in the liver function test results in most patients. There is no guidance regarding follow up, and practice varies. This study aimed to evaluate the utility of liver function te...

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Bibliographic Details
Published inJournal of laryngology and otology Vol. 137; no. 3; pp. 319 - 322
Main Authors Simpson, L, Sutherland, E, Wilkinson, D, Saman, R, Edafe, O
Format Journal Article
LanguageEnglish
Published Cambridge, UK Cambridge University Press 01.03.2023
Subjects
Abdomen
Adult
Adults
Antigens
Complications
Cytomegalovirus
Disease Progression
Enzymes
Epstein-Barr virus
Follow-Up Studies
Humans
Infectious mononucleosis
Infectious Mononucleosis - complications
Infectious Mononucleosis - diagnosis
Liver - diagnostic imaging
Liver diseases
Main Article
Mononucleosis
Patients
Phosphatase
Retrospective Studies
Ultrasonic imaging
Ultrasound
Variables
United Kingdom > UK
Acute Liver Failure
Chronic Hepatitis
Infectious Mononucleosis
Epstein-Barr Virus Infections
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Summary:Infectious mononucleosis is a relatively common acute presentation to the ENT department. There is an expected derangement in the liver function test results in most patients. There is no guidance regarding follow up, and practice varies. This study aimed to evaluate the utility of liver function tests and abdominal ultrasound in infectious mononucleosis. This was a retrospective study of all adult patients admitted under ENT with infectious mononucleosis over a five-year period. A total of 153 patients were included; 80 per cent had abnormal liver function test results at presentation. Around 50 per cent had at least one liver function test assessment following discharge. Median (interquartile range) time to resolution of liver function test results was 32 days (20-50 days); maximum time was 10 months. Six patients had in-patient abdominal ultrasound: all showed a normal liver and biliary tree. No patient developed any liver disease sequelae. The findings suggest that serial assessment of liver function is not required in immunocompetent adults with subclinical derangement in liver function.
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ISSN:0022-2151
1748-5460
DOI:10.1017/S0022215122000639