The Immunosuppressive Effect of Rabbit Anti-Mouse Macrophage Serum

Summary The suppressive effect of anti-macrophage serum (AMS) on the serum antibody response to trachoma agent antigens was studied in white Swiss mice. When given on days -1, 0 and +1, the antigen being given on day 0, AMS caused clumping of peritoneal macrophages but not peritoneal lymphocytes or...

Full description

Saved in:
Bibliographic Details
Published inThe Journal of immunology (1950) Vol. 107; no. 2; pp. 595 - 597
Main Author Isa, Abdallah M
Format Journal Article
LanguageEnglish
Published United States Am Assoc Immnol 01.08.1971
Subjects
Animals
Antibody Formation
Antigens
Chlamydia - immunology
Cytotoxicity Tests, Immunologic
Female
Fluorescent Antibody Technique
Immune Sera
Immunity
Immunoglobulin A - analysis
Immunoglobulin G - analysis
Immunoglobulin M - analysis
Immunosuppression
Lymphocytes - immunology
Macrophages - immunology
Mice
Phagocytosis
Rabbits
Spleen - immunology
Online AccessGet full text

Cover

More Information
Summary:Summary The suppressive effect of anti-macrophage serum (AMS) on the serum antibody response to trachoma agent antigens was studied in white Swiss mice. When given on days -1, 0 and +1, the antigen being given on day 0, AMS caused clumping of peritoneal macrophages but not peritoneal lymphocytes or spleen cells and interfered with the phagocytic activity of peritoneal macrophages. AMS also inhibited the primary immune response to trachoma agent antigens and specifically inhibited the production of IgM, IgA and IgG2 (7S γ2) antibodies.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.107.2.595