Implantable Nerve Conduit Made of a Self-Powered Microneedle Patch for Sciatic Nerve Repair

Peripheral nerve defects, particularly those of a larger size, pose a significant challenge in clinical practice due to their limited regenerative capacity. To tackle this challenge, an advanced self-powered enzyme-linked microneedle (MN) nerve conduit is designed and fabricated. This innovative con...

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Bibliographic Details
Published inAdvanced healthcare materials Vol. 12; no. 31; p. e2301729
Main Authors Zhang, Xiangli, Ma, Yuanya, Chen, Ziyan, Jiang, Hong, Fan, Zengjie
Format Journal Article
LanguageEnglish
Published Germany 01.12.2023
Subjects
Animals
Nerve Regeneration - physiology
Nerve Tissue
Peripheral Nerve Injuries - therapy
Prostheses and Implants
Rats
Rats, Sprague-Dawley
Sciatic Nerve - physiology
sciatic nerve repairs
enzyme biofuel cells
microneedle patches
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Summary:Peripheral nerve defects, particularly those of a larger size, pose a significant challenge in clinical practice due to their limited regenerative capacity. To tackle this challenge, an advanced self-powered enzyme-linked microneedle (MN) nerve conduit is designed and fabricated. This innovative conduit is composed of anodic and cathodic MN arrays, which contain glucose oxidase (GOx) and horseradish peroxidase (HRP) encapsulated in ZIF-8 nanoparticles, respectively. Through an enzymatic cascade reaction, this MN nerve conduit generates microcurrents that stimulate the regeneration of muscles, blood vessels, and nerve fibers innervated by the sciatic nerve, eventually accelerating the repair of sciatic nerve injury. It is clear that this self-powered MN nerve conduit will revolutionize traditional treatment methods for sciatic nerve injury and find widespread application in the field of nerve tissue repair.
ISSN:2192-2659
DOI:10.1002/adhm.202301729