Revitalizing Ancient Mitochondria with Nano‐Strategies: Mitochondria‐Remedying Nanodrugs Concentrate on Disease Control

• Published in: Advanced materials (Weinheim) Vol. 36; no. 18; pp. e2308239 - n/a
• Main Authors: Long, Xingyu, Liu, Min, Nan, Yayun, Chen, Qiaohui, Xiao, Zuoxiu, Xiang, Yuting, Ying, Xiaohong, Sun, Jian, Huang, Qiong, Ai, Kelong
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.05.2024
• Subjects: Disease control; Interdisciplinary subjects; Mitochondria; nanodrugs; Nanomaterials; oxidative stress; target delivery; nanodrugs; mitochondria; oxidative stress; target delivery
• ISSN: 0935-9648; 1521-4095; 1521-4095
• DOI: 10.1002/adma.202308239

Mitochondria, widely known as the energy factories of eukaryotic cells, have a myriad of vital functions across diverse cellular processes. Dysfunctions within mitochondria serve as catalysts for various diseases, prompting widespread cellular demise. Mounting research on remedying damaged mitochondria indicates that mitochondria constitute a valuable target for therapeutic intervention against diseases. But the less clinical practice and lower recovery rate imply the limitation of traditional drugs, which need a further breakthrough. Nanotechnology has approached favorable regiospecific biodistribution and high efficacy by capitalizing on excellent nanomaterials and targeting drug delivery. Mitochondria‐remedying nanodrugs have achieved ideal therapeutic effects. This review elucidates the significance of mitochondria in various cells and organs, while also compiling mortality data for related diseases. Correspondingly, nanodrug‐mediate therapeutic strategies and applicable mitochondria‐remedying nanodrugs in disease are detailed, with a full understanding of the roles of mitochondria dysfunction and the advantages of nanodrugs. In addition, the future challenges and directions are widely discussed. In conclusion, this review provides comprehensive insights into the design and development of mitochondria‐remedying nanodrugs, aiming to help scientists who desire to extend their research fields and engage in this interdisciplinary subject. Mitochondrial quality decrease, oxidative stress, Ca2+ dyshomeostasis, and inflammation are the major features of multiple types of diseases of mitochondrial damage. Mitochodnria‐remedying nanodrugs with different characteristics and remarkable brilliance are committed to ameliorating various diseases by rescuing mitochondria via repairing mitochondrial quality, protecting mitochondria from oxidative stress, inhibiting mPTP and inflammation response and mitochondrial bionics.