Photodynamic Therapy Directed by Three-Photon Active Rigid Plane Organic Photosensitizer

• Published in: Advanced healthcare materials Vol. 10; no. 7; p. e2001489
• Main Authors: Cao, Hongzhi, Fang, Bin, Liu, Jiejie, Shen, Yu, Shen, Jie, Xiang, Pan, Zhou, Qin, De Souza, Senio Campos, Li, Dandan, Tian, Yupeng, Luo, Lei, Zhang, Zhongping, Tian, Xiaohe
• Format: Journal Article
• Language: English
• Published: Germany 01.04.2021
• Subjects: Cell Death; Photochemotherapy; Photons; Photosensitizing Agents - pharmacology; Photosensitizing Agents - therapeutic use; Reactive Oxygen Species; three-photon absorption; rigid planar photosensitizers; photodynamic therapy; reactive oxygen species
• ISSN: 2192-2659
• DOI: 10.1002/adhm.202001489

Multi-photon photosensitizers (PSs) could significantly improve the efficacy of photodynamic therapy due to the long-wavelength favorability for deeper tissue penetration and lower biological damage. However, most studies are limited to single-photon or two-photon PSs at a relatively short-wave excitation window. To overcome this barrier, we rationally design a series of rigid plane compounds with efficient reactive oxygen species (ROS) production in vitro under laser irradiation. Furthermore, the studies show that one of the compounds (U-TsO) could induce rapid multi-types of cell death under three-photon exposure, suggesting a promising clinical outcome in ex vivo 3D multicellular tumor spheroid. This work offers a novel strategy to construct functional materials with competitive multi-photon photodynamic therapy (PDT) outcome.