When cyclin‐dependent kinases meet viral infections, including SARS‐CoV‐2

• Published in: Journal of medical virology Vol. 94; no. 7; pp. 2962 - 2968
• Main Authors: Yan, Yan, Tang, Yan‐dong, Zheng, Chunfu
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.07.2022; John Wiley and Sons Inc
• Subjects: Antiviral Agents - pharmacology; Antiviral Agents - therapeutic use; CDKs; Cell division; COVID-19; Cyclin-Dependent Kinases - metabolism; Cyclin-Dependent Kinases - therapeutic use; DNA viruses; Gene regulation; Humans; Infections; Kinases; Protein kinase; Review; Reviews; RNA viruses; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Therapeutic targets; Viral diseases; viral infection; Viral infections; Virology; Virus Diseases - drug therapy; RNA viruses; viral infection; DNA viruses; CDKs
• ISSN: 0146-6615; 1096-9071
• DOI: 10.1002/jmv.27719

Cyclin‐dependent kinases (CDKs) are protein kinases that play a key role in cell division and transcriptional regulation. Recent studies have demonstrated the critical roles of CDKs in various viral infections. However, the molecular processes underpinning CDKs' roles in viral infection and host antiviral defense are unknown. This minireview briefly overviews CDKs' functions and highlights the most recent discoveries of CDKs' emerging roles during viral infections, thereby providing a scientific and theoretical foundation for antiviral regulation and shedding light on developing novel drug targets and therapeutic strategies against viral infection.