Correlation between retinal oxygen saturation and the haemodynamic parameters of the ophthalmic artery in healthy subjects

• Published in: Acta ophthalmologica (Oxford, England) Vol. 100; no. 7; pp. e1489 - e1495
• Main Authors: Král, Michal, Svrčinová, Tereza, Hok, Pavel, Dorňák, Tomáš, Rybáriková, Martina, Mareš, Jan, Kaňovský, Petr, Šín, Martin
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.11.2022; John Wiley and Sons Inc
• Subjects: Adult; Arterioles; automatic retinal oximetry; Blood flow; Blood Flow Velocity; Blood vessels; Doppler effect; Doppler imaging; Eye; Healthy Volunteers; Hemodynamics; Hemoglobin; Hemoglobins; Humans; Ophthalmic Artery; Original; Oximetry - methods; Oxygen; Oxygen consumption; Oxygen Saturation; Retina; Retinal Artery - diagnostic imaging; Retinal Artery - physiology; retinal vessel oxygen saturation; Spectrophotometry; Statistical analysis; Young Adult; Doppler imaging; ophthalmic artery; retinal vessel oxygen saturation; automatic retinal oximetry
• ISSN: 1755-375X; 1755-3768; 1755-3768
• DOI: 10.1111/aos.15189

Purpose The aim of the study was to obtain the values of oxygen saturation in retinal vessels and ophthalmic blood flow parameters in a healthy Caucasian population and assess whether the oximetry parameters are affected by the flow rate or the vascular resistance. Methods The spectrophotometric retinal oximetry and colour Doppler imaging (CDI) of retinal vessels were successfully performed with 52 healthy subjects (average age 29.7 ± 5.6 years). The retinal oximeter simultaneously measures the wavelength difference of haemoglobin oxygen saturation in retinal arterioles and venules. The arteriolar and venular saturation in both eyes was measured. The peak systolic (PSV) end diastolic (EDV) velocities, resistive (RI) and pulsatility (PI) indices were obtained for both eyes using CDI in the ophthalmic artery. A paired t‐test and two sample t‐tests were used for statistical analyses. The correlation was assessed using the Pearson coefficient correlation. Results The mean oxygen saturation level was 96.9 ± 3.0% for the retinal arterioles and 65.0 ± 5.1% for the retinal venules. The A‐V difference was 31.8 ± 4.6%. The mean of the measured haemodynamic parameters was PSV 46.6 ± 9.4 cm/s, EDV 12.0 ± 3.5 cm/s, PI 1.68 ± 0.38 and RI 0.74 ± 0.05. No significant difference in oxygen saturation and haemodynamic parameters was found between the left and the right eyes or the dominant and non‐dominant eye. The oximetry and ultrasound values were sex independent. The Pearson correlation coefficient demonstrated a significant yet weak negative correlation between A‐V difference and RI (r = −0.321, p = 0.020). Conclusions A negative correlation between A‐V difference and resistance index was observed, suggesting that reduced oxygen consumption may reflect the increased vascular tone of the ophthalmic vessels, which is likely determined by autoregulatory mechanisms.