Solvent‐Free Strategy for Direct Access to Versatile Quaternary Ammonium Salts with Complete Atom Economy

A solvent‐free method for the synthesis of quaternary ammonium salts (QAS) by iodoquaternization of alkenes with N‐heteroarenes was reported. Its advantages lie in energy‐saving and clean production by using iodine as the oxidant and manual grinding the starting materials, together with the complete...

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Published inChemSusChem Vol. 15; no. 12; pp. e202200529 - n/a
Main Authors Fan, Weibin, Zhang, Yuan, Li, Yinghua, Zhang, Wei, Huang, Deguang
Format Journal Article
LanguageEnglish
Published Germany Wiley Subscription Services, Inc 22.06.2022
Subjects
Alkenes
atom economy
Clean energy
Fluorescence
Iodine
mechanochemistry
organic chemistry
Oxidizing agents
Protease inhibitors
pyridinium
Quaternary ammonium salts
solvent-free
Solvents
atom economy
solvent-free
mechanochemistry
organic chemistry
pyridinium
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Summary:A solvent‐free method for the synthesis of quaternary ammonium salts (QAS) by iodoquaternization of alkenes with N‐heteroarenes was reported. Its advantages lie in energy‐saving and clean production by using iodine as the oxidant and manual grinding the starting materials, together with the complete atom economy and low process mass intensity (PMI) value. Demonstrated by 50 examples, the generated QAS was proved to be able to produce valuable chemicals, such as biological protease inhibitors, anti‐cancer agents, and organic fluorescent materials. No atom wasted: A solvent‐free method for the synthesis of quaternary ammonium salts is explored. This method is characterized by clean production and complete atom economy. The products show application potentials in pharmaceutical chemistry and photo‐electrochemistry.
Bibliography:ObjectType-Article-1
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ISSN:1864-5631
1864-564X
DOI:10.1002/cssc.202200529