Guaiane‐Type Sesquiterpenes from the Stems of Fissistigma oldhamii

Two new guaiane‐type sesquiterpenes dysodensiols J and L, one new natural product dysodensiol K together with four known biogenetically related guaiane‐type sesquiterpenes were isolated from the stems of Fissistigma oldhamii. Their structures were elucidated by detailed analysis of NMR, HR‐ESI‐MS, I...

Full description

Saved in:
Bibliographic Details
Published inChemistry & biodiversity Vol. 20; no. 5; pp. e202300338 - n/a
Main Authors Wu, Mei‐Zhu, Xu, Bing‐Quan, Zhang, Xiao‐Zheng, Liu, Sha, Luo, You‐Ping, Zhou, Xue‐Ming, Chen, Guang‐Ying
Format Journal Article
LanguageEnglish
Published Switzerland Wiley Subscription Services, Inc 01.05.2023
Subjects
Annonaceae - chemistry
Cell proliferation
Fissistigma oldhamii
Molecular Structure
Natural products
NMR
norisoprenoid
Nuclear magnetic resonance
sesquiterpene
Sesquiterpenes
Sesquiterpenes - chemistry
Sesquiterpenes - pharmacology
Sesquiterpenes, Guaiane - pharmacology
synoviocytes
synoviocytes
Fissistigma oldhamii
norisoprenoid
sesquiterpene
Online AccessGet full text

Cover

More Information
Summary:Two new guaiane‐type sesquiterpenes dysodensiols J and L, one new natural product dysodensiol K together with four known biogenetically related guaiane‐type sesquiterpenes were isolated from the stems of Fissistigma oldhamii. Their structures were elucidated by detailed analysis of NMR, HR‐ESI‐MS, IR and Optical rotations data. Compound 1 contains an uncommon five‐membered ether ring. The inhibitory effect of all compounds on the proliferation of primary synovial cells was evaluated. Compound 3 showed inhibitory activity with an IC50 value of 6.8 μM. Compounds 5–7 exhibited moderate inhibitory activity with IC50 values of 23.8, 26.6, and 27.1 μM, respectively.
Bibliography:Mei‐Zhu Wu and Bing‐Quan Xu are co‐first author.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.202300338