Catalytic Synthesis of Silanols by Hydroxylation of Hydrosilanes: From Chemoselectivity to Enantioselectivity

As a crucial class of functional molecules in organosilicon chemistry, silanols are found valuable applications in the fields of modern science and will be a potentially powerful framework for biologically active compounds or functional materials. It has witnessed an increasing demand for non‐natura...

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Published inChemistry : a European journal Vol. 30; no. 2; pp. e202302458 - n/a
Main Authors Huang, Wei‐Sheng, Xu, Hao, Yang, Hua, Xu, Li‐Wen
Format Journal Article
LanguageEnglish
Published Germany Wiley Subscription Services, Inc 08.01.2024
Subjects
Bioactive compounds
Biological activity
Chemical synthesis
Chemistry
Electrochemistry
Enantiomers
Functional materials
Hydroxylation
organocatalyst
Oxidation
silanol
Silicon
silicon-stereogenic
transition metal catalyst
oxidation
silicon-stereogenic
silanol
organocatalyst
transition metal catalyst
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Summary:As a crucial class of functional molecules in organosilicon chemistry, silanols are found valuable applications in the fields of modern science and will be a potentially powerful framework for biologically active compounds or functional materials. It has witnessed an increasing demand for non‐natural organosilanols, as well as the progress in the synthesis of these structural features. From the classic preparative methods to the catalytic selective oxidation of hydrosilanes, electrochemical hydrolysis of hydrosilanes, and then the construction of the most challenging silicon‐stereogenic silanols. This review summarized the progress in the catalyzed synthesis of silanols via hydroxylation of hydrosilanes in the last decade, with a particular emphasis on the latest elegant developments in the desymmetrization strategy for the enantioselective synthesis of silicon‐stereogenic silanols from dihydrosilanes. Demand for structurally diverse organosilanols has been increasing, and thus this Review summarized the progress in the catalyzed synthesis of silanols via hydroxylation of hydrosilanes in the last decade, with a particular emphasis on the latest elegant developments in the desymmetrization strategy for the enantioselective synthesis of silicon‐stereogenic silanols from dihydrosilanes.
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ISSN:0947-6539
1521-3765
1521-3765
DOI:10.1002/chem.202302458