New Eudesmane Sesquiterpenoids from Salvia plebeia R. Br

• Published in: Chemistry & biodiversity Vol. 14; no. 8
• Main Authors: Ma, Lie‐Feng, Wang, Peng‐Fei, Wang, Ji‐Dong, Tong, Xiang‐Min, Shan, Wei‐Guang, Zhang, Hui, Zhan, Zha‐Jun
• Format: Journal Article
• Language: English
• Published: Switzerland Wiley Subscription Services, Inc 01.08.2017
• Subjects: Amides; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Biotechnology; Cell Line, Tumor; Cell Proliferation - drug effects; Drugs, Chinese Herbal - chemistry; Drugs, Chinese Herbal - isolation & purification; Drugs, Chinese Herbal - pharmacology; Ethanol; Eudesmane; Humans; Leukemia; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Conformation; Myeloid leukemia; NMR; Nuclear magnetic resonance; Salplebeone; Salvia - chemistry; Salvia - metabolism; Salvia plebeia R. Br; Sesquiterpenes, Eudesmane - chemistry; Sesquiterpenes, Eudesmane - isolation & purification; Sesquiterpenes, Eudesmane - pharmacology; Sesquiterpenoids; Tumor cell lines; Salplebeone; Eudesmane; Sesquiterpenoids; Salvia plebeia R. Br
• ISSN: 1612-1872; 1612-1880
• DOI: 10.1002/cbdv.201700127

Three new sesquiterpenoids, salplebeones A – C (1 – 3), were isolated from the ethanol‐soluble extract of the aerial part of Salvia plebeia R. Br. Their structures were established by detailed analysis of NMR and MS spectra. Salplebeone A was an eudesmane lactone, while salplebeones B and C were rare eudesmane sesquiterpenoids, containing 12,8‐lactam groups. Antiproliferative activities of salplebeones A – C to myeloid leukemia cell lines were evaluated.