Simultaneous Biofilm Disruption, Bacterial Killing, and Inflammation Elimination for Wound Treatment Using Silver Embellished Polydopamine Nanoplatform

• Published in: Small (Weinheim an der Bergstrasse, Germany) Vol. 20; no. 36; pp. e2400927 - n/a
• Main Authors: Ding, Meng, Zhang, Yu, Li, Xiaoye, Li, Qiang, Xiu, Weijun, He, Ao, Dai, Zhuo, Dong, Heng, Shan, Jingyang, Mou, Yongbin
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.09.2024
• Subjects: Animals; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Bacteria; bacterial biofilm; Biofilms; Biofilms - drug effects; dopamine; Indoles - chemistry; Indoles - pharmacology; infected wound; Inflammation; Inflammation - drug therapy; Inflammation - pathology; Membrane structures; Mice; Nanoparticles - chemistry; photothermal; Photothermal conversion; Polymers - chemistry; Polymers - pharmacology; Radiation damage; Silver; Silver - chemistry; Silver - pharmacology; Staphylococcus aureus - drug effects; Wound healing; Wound Healing - drug effects; photothermal; infected wound; inflammation; dopamine; bacterial biofilm
• ISSN: 1613-6810; 1613-6829; 1613-6829
• DOI: 10.1002/smll.202400927

Due to the presence of spatial barriers, persistent bacteria, and excessive inflammation in bacteria biofilm‐infected wounds, current nanoplatforms cannot effectively address these issues simultaneously during the therapeutic process. Herein, a novel biomimetic photothermal nanoplatform integrating silver and polydopamine nanoparticles (Ag/PDAs) that can damage biofilms, kill bacterial persisters, and reduce inflammation for wound treatment is presented. These findings reveal that Ag/PDAs exhibit a broad‐spectrum antimicrobial activity through direct damage to the bacterial membrane structure. Additionally, Ag/PDAs demonstrate a potent photothermal conversion efficiency. When combined with near‐infrared (NIR) irradiation, Ag/PDAs effectively disrupt the spatial structure of biofilms and synergistically eradicate the resident bacteria. Furthermore, Ag/PDAs show remarkable anti‐inflammatory properties in counteracting bacterium‐induced macrophage polarization. The in vivo results confirm that the topical application of Ag/PDAs significantly suppress Staphylococcus aureus biofilm‐infected wounds in murine models, concurrently facilitating wound healing. This research provides a promising avenue for the eradication of bacterial biofilms and the treatment of biofilm‐infected wounds. A novel AgNPs and PDAs‐based nano platform (Ag/PDAs) offering broad‐spectrum antibacterial activity and biofilm disruption under 808 nm laser irradiation. Ag/PDAs modulate inflammation by affecting macrophage polarization, promoting tissue healing in biofilm‐infected wounds in mice.