BODIPY as a Multifunctional Theranostic Reagent in Biomedicine: Self‐Assembly, Properties, and Applications

• Published in: Advanced materials (Weinheim) Vol. 35; no. 18; pp. e2207546 - n/a
• Main Authors: Cheng, Hong‐Bo, Cao, Xiaoqiao, Zhang, Shuchun, Zhang, Keyue, Cheng, Yang, Wang, Jiaqi, Zhao, Jing, Zhou, Liming, Liang, Xing‐Jie, Yoon, Juyoung
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.05.2023
• Subjects: Aqueous environments; Biomedical materials; biomedicine; Boron - chemistry; boron dipyrromethene (BODIPY); fluorescent dyes; Indicators and Reagents; Materials science; Medical imaging; Nanoparticles - chemistry; Photodynamic therapy; Precision Medicine; Reagents; Self-assembly; Smart materials; theranostic reagents; self-assembly; boron dipyrromethene (BODIPY); biomedicine; fluorescent dyes; theranostic reagents
• ISSN: 0935-9648; 1521-4095
• DOI: 10.1002/adma.202207546

The use of boron dipyrromethene (BODIPY) in biomedicine is reviewed. To open, its synthesis and regulatory strategies are summarized, and inspiring cutting‐edge work in post‐functionalization strategies is highlighted. A brief overview of assembly model of BODIPY is then provided: BODIPY is introduced as a promising building block for the formation of single‐ and multicomponent self‐assembled systems, including nanostructures suitable for aqueous environments, thereby showing the great development potential of supramolecular assembly in biomedicine applications. The frontier progress of BODIPY in biomedical application is thereafter described, supported by examples of the frontiers of biomedical applications of BODIPY‐containing smart materials: it mainly involves the application of materials based on BODIPY building blocks and their assemblies in fluorescence bioimaging, photoacoustic imaging, disease treatment including photodynamic therapy, photothermal therapy, and immunotherapy. Lastly, not only the current status of the BODIPY family in the biomedical field but also the challenges worth considering are summarized. At the same time, insights into the future development prospects of biomedically applicable BODIPY are provided. Boron dipyrromethene (BODIPY) is an outstanding fluorescent molecule, with high molar absorption coefficients and good chemical stability. Improvements in self‐assembly technology have fueled the applications of BODIPY in diagnosis and treatment. This review summarizes the molecular structure design and self‐assembly strategy of BODIPY, and its applications as a multifunctional theranostic agent in biomedical fields.