Single‐Atom Nanozyme Based on Nanoengineered Fe–N–C Catalyst with Superior Peroxidase‐Like Activity for Ultrasensitive Bioassays

• Published in: Small (Weinheim an der Bergstrasse, Germany) Vol. 15; no. 48; pp. e1901485 - n/a
• Main Authors: Cheng, Nan, Li, Jin‐Cheng, Liu, Dong, Lin, Yuehe, Du, Dan
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.11.2019
• Subjects: Ascorbic acid; Bioassays; Carbon nanotubes; Fe‐N‐C catalysis; Hydrogen peroxide; Nanotechnology; paper bioassays; Peroxidase; peroxidase‐like activity; Single atom catalysts; single‐atom nanozyme; Fe-N-C catalysis; single-atom nanozyme; peroxidase-like activity; paper bioassays
• ISSN: 1613-6810; 1613-6829; 1613-6829
• DOI: 10.1002/smll.201901485

Single‐atom catalysts are becoming a hot research topic owing to their unique characteristics of maximum specific activity and atomic utilization. Herein, a new single‐atom nanozyme (SAN) based on single Fe atoms anchored on N‐doped carbons supported on carbon nanotube (CNT/FeNC) is proposed. The CNT/FeNC with robust atomic Fe–Nx moieties is synthesised, showing superior peroxidase‐like activity. Furthermore, the CNT/FeNC is used as the signal element in a series of paper‐based bioassays for ultrasensitive detection of H2O2, glucose, and ascorbic acid. The SAN provides a new type of signal element for developing various biosensing techniques. A new single atom nanozyme (SAN), carbon nanotube supported single Fe atoms anchored on N‐doped carbon (CNT/FeNC), was developed for bioanalytical applications. The CNT/FeNC with robust atomic Fe–Nx moieties showed superior peroxidase‐like activity. A series of paper based bioassays were developed using SAN as the signal element.