Recent Advances in Constructing Higher‐Order DNA Structures

• Published in: Chemistry, an Asian journal Vol. 17; no. 5; pp. e202101315 - n/a
• Main Authors: Wang, Jing, Wang, Dong‐Xia, Liu, Bo, Jing, Xiao, Chen, Dan‐Ye, Tang, An‐Na, Cui, Yun‐Xi, Kong, De‐Ming
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.03.2022
• Subjects: Assembly; Base Pairing; Biocompatibility; Biomedical materials; Biosensing Techniques; Biosensors; Chemistry; Deoxyribonucleic acid; DNA; DNA - chemistry; DNA nanostructures; DNA nanotechnology; DNA-based materials; higher-order; Medical materials; Nanostructure; Nanostructures - chemistry; Nanotechnology; self-assembly; DNA-based materials; self-assembly; DNA nanotechnology; higher-order; DNA nanostructures
• ISSN: 1861-4728; 1861-471X
• DOI: 10.1002/asia.202101315

Molecular self‐assembly is widely used in the fields of biosensors, molecular devices, efficient catalytic materials, and medical biomaterials. As the carrier of genetic information, DNA is a kind of biomacromolecule composed of deoxyribonucleotide units. DNA nanotechnology extends DNA of its original properties as a molecule that stores and transmits genetic information from its biological environment by taking advantage of its unique base pairing and inherent biocompatibility to produce structurally‐defined supramolecular structures. With the continuously development of DNA technology, the assembly method of DNA nanostructures is not only limited on the basis of DNA hybridization but also other biochemical interactions. In this review, we summarize the latest methods used to construct higher‐order DNA structures. The problems of DNA nanostructures are discussed and the future directions in this field are provided. Recent advances in DNA nanotechnology, focusing on the analysis and highlighting methods of building DNA structures in recent years are summarized in this review.Furthermore, future directions in this field are provided.