Carpelipines C and D, Two Anti‐Inflammatory Germacranolides from the Flowers of Carpesium lipskyi Winkl. (Asteraceae)

• Published in: Chemistry & biodiversity Vol. 19; no. 7; pp. e202200415 - n/a
• Main Authors: Zhong, Weihong, Li, Min, Han, Shan, Sun, Jie, Cao, Lan, Mu, Zejing, Du, Xiaolang, Cui, Yushun, Feng, Yulin, Zhong, Guoyue
• Format: Journal Article
• Language: English
• Published: Switzerland Wiley Subscription Services, Inc 01.07.2022
• Subjects: Analgesics; anti-inflammation; Asteraceae; carpelipines C and D; Carpesium lipskyi; Crystallography; Flowers; germacranolide; Herbal medicine; Inflammatory diseases; Lipopolysaccharides; MAP kinase; Nitric-oxide synthase; Oxidative stress; Signal transduction; carpelipines C and D; Carpesium lipskyi; anti-inflammation; germacranolide; Asteraceae
• ISSN: 1612-1872; 1612-1880
• DOI: 10.1002/cbdv.202200415

Two new germacranolides, carpelipine C (1) and carpelipine D (2), together with four known ones (3–6), were isolated from Carpesium lipskyi Winkl. flowers, a folk Tibetan herbal medicine with antipyretic‐analgesic and anti‐inflammatory effects. The chemical structures of new structure were illuminated by diversified spectroscopic and X‐ray crystallographic analyses. Compounds 1 and 3 dramatically suppressed the synthesis of NO and decreased pre‐inflammatory protein expression of iNOS and COX‐2 in LPS‐induced RAW264.7 cells. Furthermore, it was revealed that NF‐κB/MAPK signaling pathway were involved in the anti‐inflammatory process of 1 and 3, and their effects on reducing oxidative stress by activating Nrf2/HO‐1 pathway were also measured. This article indicated that the traditional use of C. lipskyi to treat inflammatory diseases has a certain rationality.