Smart Enzyme‐Like Polyphenol‐Copper Spray for Enhanced Bacteria‐Infected Diabetic Wound Healing

• Published in: Small (Weinheim an der Bergstrasse, Germany) Vol. 20; no. 22; pp. e2308295 - n/a
• Main Authors: Shao, Nannan, Huang, Siyan, Huang, Yueyue, Pan, Mengmeng, Xie, Yuyu, Chen, Qizhu, Chen, Chunxiu, Pan, Jingye, Zhou, Yunlong
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.05.2024
• Subjects: Acidic oxides; acidic spray; Animals; antioxidant therapy; Bacteria; bacteria clearance; Bacterial Infections - drug therapy; Copper; Copper - chemistry; Copper - pharmacology; Diabetes; Diabetes Mellitus, Experimental; diabetic wound healing; Enzymes; enzyme‐like activity; Hydrogen peroxide; Hydrogen Peroxide - chemistry; Hydrogen Peroxide - metabolism; Hydroxyl radicals; Medical materials; Mice; Nanocomposites; Nanocomposites - chemistry; Polyphenols - chemistry; Polyphenols - pharmacology; Sterilization; Wound healing; Wound Healing - drug effects; acidic spray; enzyme‐like activity; bacteria clearance; antioxidant therapy; diabetic wound healing
• ISSN: 1613-6810; 1613-6829
• DOI: 10.1002/smll.202308295

Developing functional medical materials is urgent to treat diabetic wounds with a high risk of bacterial infections, high glucose levels and oxidative stress. Here, a smart copper‐based nanocomposite acidic spray has been specifically designed to address this challenge. This copper‐based nanocomposite is pH‐responsive and has multienzyme‐like properties. It enables the spray to effectively eliminate bacteria and alleviate tissue oxidative pressure, thereby accelerating the healing of infected diabetic wounds. The spray works by generating hydroxyl radicals through catalysing H2O2, which has a high sterilization efficiency of 97.1%. As alkaline micro‐vessel leakage neutralizes the acidic spray, this copper‐based nanocomposite modifies its enzyme‐like activity to eliminate radicals. This reduces the level of reactive oxygen species in diabetic wounds by 45.3%, leading to a similar wound‐healing effect between M1 diabetic mice and non‐diabetic ones by day 8. This smart nanocomposite spray provides a responsive and regulated microenvironment for treating infected diabetic wounds. It also offers a convenient and novel approach to address the challenges associated with diabetic wound healing. A smart acidic spray containing copper‐based nanocomposites (TCNCs) with adjustable enzyme‐like activities has been developed. In acidic conditions, it generates hydroxyl radicals, effectively eliminating bacteria. As wound exudate neutralizes the acidic buffer and catalase decomposes H2O2 in vivo, TCNCs can help to remove reactive oxygen species, facilitate the transition to the tissue regeneration stage and expedite wound healing.